Burke was born in Dublin, Ireland, to a prosperous solicitor father (Richard; d. 1761) of the Church of Ireland. It is unclear if this is the same Richard Burke who converted from Catholicism. His mother Mary (c. 1702 – 1770), whose maiden name was Nagle, belonged to the Roman Catholic Church and came from an impoverished but genteel County Cork family. (The name de Búrca, anglicised as Burke, is the Irish language version of the Norman name Burgh or de Burgh, the name of a family that settled in Ireland following the Norman invasion of Ireland by Henry II of England in 1172.) Burke was raised in his father's faith and remained throughout his life a practising Anglican, unlike his sister Juliana who was brought up as and remained a Roman Catholic. Although never denying his Irishness, Burke often described himself as "an Englishman". This was in an age "before 'Celtic nationalism' sought to make Irishness and Englishness incompatible". As a child he sometimes spent time away from the unhealthy air of Dublin with his mother's family in the Blackwater Valley. He received his early education at a Quaker school in Ballitore, some 30 miles (48 km) from Dublin, and remained in correspondence with his schoolmate Mary Leadbeater, the daughter of the school's owner, throughout his life.

In 1744 he proceeded to Trinity College, Dublin. In 1747, he set up a Debating Club, known as Edmund Burke's Club, which in 1770 merged with the Historical Club to form the College Historical Society, now the oldest undergraduate society in the world. The minutes of the meetings of Burke's club remain in the collection of the Historical Society. He graduated in 1748. Burke's father wished him to study for the law, and with this object he went to London in 1750 and entered the Middle Temple, but soon thereafter he gave up his legal studies in order to travel in Continental Europe. After giving up law, he attempted to earn his livelihood through writing.

The late Lord Bolingbroke's Letters on the Study and Use of History was published in 1752 and his collected works appeared in 1754. This provoked Burke into writing his first published work, A Vindication of Natural Society: A View of the Miseries and Evils Arising to Mankind, appearing in Spring 1756. Burke imitated Lord Bolingbroke's style and ideas in a reductio ad absurdum of his arguments for atheistic rationalism, demonstrating their absurdity. Burke claimed that Bolingbroke's arguments against revealed religion could apply to all social and civil institutions. Lord Chesterfield and Bishop Warburton (and others) initially thought that the work was genuinely by Bolingbroke rather than a satire. All the reviews of the work were positive, with critics especially appreciative of Burke's quality of writing. Some reviewers failed to notice the ironic nature of the book, which led to Burke writing in the preface to the second edition (1757) that it was a satire. Richard Hurd believed that Burke's imitation was near-perfect and that this defeated his purpose.

In 1757 Burke published a treatise on aesthetics, A Philosophical Enquiry into the Origin of Our Ideas of the Sublime and Beautiful, which attracted the attention of prominent Continental thinkers such as Denis Diderot and Immanuel Kant. It was his only purely philosophical work, and when asked by Sir Joshua Reynolds and Dr. Laurence to expand it thirty years later, Burke replied that he was no longer fit for abstract speculation (Burke had written it before he was 19).

On 25 February 1757 Burke signed a contract with Robert Dodsley to write a "history of England from the time of Julius Caesar to the end of the reign of Queen Anne", its length being eighty quarto sheets (640 pages), under 400,000 words. It was to be submitted for publication by Christmas 1758. Burke actually completed to the year 1216, and never published the work. It was not published until 1812 in Burke's collected works under the title of An Essay Towards an Abridgement of the English History, after Burke's death. G.M. Young did not value Burke's history and claimed that it was "demonstrably a translation from the French". Lord Acton, on commenting on the story that Burke stopped his history because David Hume published his, said "it is ever to be regretted that the reverse did not occur".

The following year, with Dodsley, he created the influential Annual Register, a publication in which various authors evaluated the international political events of the previous year. The extent to which Burke personally contributed to the Annual Register is contested. Robert Murray in his biography of Burke quotes the Register as evidence of Burke's opinions, yet Philip Magnus in his biography does not directly cite it as a reference. Burke remained its chief editor until at least 1789 and there is no evidence that any other writer contributed to it before 1766.

In London, Burke knew many of the leading intellectuals and artists, including Samuel Johnson, David Garrick, Oliver Goldsmith, and Joshua Reynolds. Edward Gibbon described him as, 'the most eloquent and rational madman that I ever knew.'

On 12 March 1757 he married Jane Mary Nugent (1734 – 1812), daughter of a Catholic physician who had treated him at Bath. His son Richard was born on 9 February 1758. Another son, Christopher, died in infancy.

At about this same time, Burke was introduced to William Gerard Hamilton (known as "Single-speech Hamilton"). When Hamilton was appointed Chief Secretary for Ireland, Burke accompanied him to Dublin as his private secretary, a position he maintained for three years. In 1765 Burke became private secretary to liberal Whig statesman Charles Watson-Wentworth, the Marquess of Rockingham, at the time Prime Minister of Great Britain, who remained Burke's close friend and associate until his premature death in 1782.

In December 1765 Burke entered the British Parliament as a member of the House of Commons for Wendover, a pocket borough in the control of Lord Fermanagh, later 2nd Earl Verney, a close political ally of Rockingham. After Burke's maiden speech, William Pitt the Elder said Burke had "spoken in such a manner as to stop the mouths of all Europe" and that the Commons should congratulate itself on acquiring such a member.

In 1769 Burke published, in reply to Grenvillite pamphlet The Present State of the Nation, his pamphlet on Observations on a Late State of the Nation. Surveying the finances of France, Burke predicts "some extraordinary convulsion in that whole system".

In the same year he purchased the small estate of Gregories near Beaconsfield. The 600-acre (2.4 km²) estate was purchased with mostly borrowed money, and though it contained an art collection that included works by Titian, Gregories nevertheless would prove to be a heavy financial burden on the MP in the following decades. Burke was never able to fully pay for the estate. His speeches and writings had now made him famous, and among other effects had brought about the suggestion that he was the author of the Letters of Junius.

Burke took a leading role in the debate over the constitutional limits to the executive authority of the King. He argued strongly against unrestrained royal power and for the role of political parties in maintaining a principled opposition capable of preventing abuses by the monarch or by specific factions within the government. His most important publication in this regard was his Thoughts on the Cause of the Present Discontents of 23 April 1770. Burke identified the "discontents" as stemming from the "secret influence" of a neo-Tory group he calls the "king's friends", whose system "comprehending the exterior and interior Administrations, is commonly called, in the technical language of the Court, Double Cabinet". Britain needed a party which had "an unshaken adherence to principle, and attachment to connexion, against every allurement of interest". Party divisions "whether operating for good or evil, are things inseparable from free government".

During 1771 Burke wrote a Bill which would, if passed, have given juries the right to determine what was libel. Burke spoke in favour of the Bill but it was opposed by some, including Charles James Fox, and was not passed. Fox, when introducing his own Bill in 1791, repeated almost verbatim the text of Burke's Bill without acknowledgement. Burke was also prominent in securing the right to publish debates held in Parliament.

Speaking in a parliamentary debate on the prohibition on the export of grain on 16 November 1770, Burke argued in favour of a free market in corn: "There are no such things as a high, & a low price that is encouraging, & discouraging; there is nothing but a natural price, which grain brings at an universal market." In 1772 Burke was instrumental in passing the Repeal of Certain Laws Act 1772, which repealed various old laws against dealers and forestallers in corn.

In the Annual Register for 1772 (published in July 1773) Burke condemned the Partition of Poland. He saw it as "the first very great breach in the modern political system of Europe" and upsetting the balance of power in Europe.

In 1774 he was elected member for Bristol, at the time "England's second city" and a large constituency with a genuine electoral contest. His Speech to the Electors at Bristol at the Conclusion of the Poll was noted for its defence of the principles of representative democracy against the notion that elected officials should be delegates.

In May 1778 Burke supported a motion in Parliament to revise the restrictions on Irish trade. However his constituents in Bristol, a great trading city, urged Burke to oppose free trade with Ireland. Burke resisted these demands and said: "If, from this conduct, I shall forfeit their suffrages at an ensuing election, it will stand on record an example to future representatives of the Commons of England, that one man at least had dared to resist the desires of his constituents when his judgment assured him they were wrong". Burke published Two Letters to Gentlemen of Bristol on the Bills relative to the Trade of Ireland in which he espoused "some of the chief principles of commerce; such as the advantage of free intercourse between all parts of the same kingdom...the evils attending restriction and monopoly...and that the gain of others is not necessarily our loss, but on the contrary an advantage by causing a greater demand for such wares as we have for sale". Burke also supported Sir George Savile's attempts to repeal some of the penal laws against Catholics. This support for unpopular causes, notably free trade with Ireland and Catholic emancipation, led to Burke losing his seat in 1780. He also called capital punishment "the Butchery which we call justice" in 1776 and in 1780 Burke condemned the use of the pillory for two men convicted for attempting to practice sodomy.

For the remainder of his parliamentary career, Burke sat for Malton, another pocket borough controlled by the Marquess of Rockingham.

Burke expressed his support for the grievances of the American colonies under the government of King George III and his appointed representatives. On 19 April 1774 Burke made a speech (published in January 1775) on a motion to repeal the tea duty. On 22 March 1775 Burke gave a speech (published in May 1775) on reconciliation with America. The administration of Lord North (1770 – 1782) tried to defeat the colonists' rebellion by military force. British and American forces clashed in 1775 and in 1776 came the American Declaration of Independence. Burke was appalled by celebrations in Britain of the defeat of the Americans at New York and Pennsylvania. He claimed the English national character was being changed by this authoritarianism. In Burke's view the British government was fighting "the American English" ("our English Brethren in the Colonies"), with a German-descended King employing "the hireling sword of German boors and vassals" to destroy British colonists' English liberties. On American independence, Burke wrote: "I do not know how to wish success to those whose Victory is to separate from us a large and noble part of our Empire. Still less do I wish success to injustice, oppression and absurdity". In 1780 during the Gordon Riots, Burke was a particular target for the rioters, and his home had to be placed under armed guard by the military.

The fall of North led to Rockingham being recalled to power in March 1782. Burke became Paymaster of the Forces and a Privy Councillor, but without a seat in the Cabinet. Rockingham's unexpected death in July of 1782 and his replacement as Prime Minister by Shelburne put an end to his administration after only a few months. However Burke did manage to pass two Acts. The Paymaster General Act 1782 ended the post as a lucrative sinecure. Previously, Paymasters had been able to draw on money from the Treasury at their discretion. Now they were to put the money they had requested to withdraw from the Treasury into the Bank of England, from where it was to be withdrawn for specific purposes. The Treasury would receive monthly statements of the Paymaster's balance at the Bank. This Act was repealed by Shelburne's administration but the Act which replaced it repeated verbatim almost the whole text of Burke's Act. The Civil List and Secret Service Money Act 1782 was a watered down version of Burke's original intentions as outlined in his famous Speech on Economical Reform of 11 February 1780. However he managed to abolish 134 offices in the royal household and civil administration. The third Secretary of State and the Board of Trade were abolished and pensions were limited and regulated. The Act was projected to save £72,368 a year. In February 1783 Burke resumed the post of Paymaster of the Forces when Shelburne's government fell and was replaced by a coalition headed by North and including Charles James Fox. The coalition fell in 1783, and was succeeded by the long Tory administration of William Pitt the Younger, which lasted until 1801. Burke was accordingly in opposition for the remainder of his political life.

Burke’s interaction with the British dominion of India began well before the Hastings Trial. Previous to the impeachment, Parliament dealt with the Indian issue for two decades, this trial was the pinnacle of years of unrest and deliberation. In 1781 Burke was first able to delve into the issues surrounding the East India Company when he was appointed Chairman of the Commons’ Select Committee on East Indian Affair – from that point until the end of the trial; India was Burke’s primary concern. This committee was charged “to investigate alleged injustices in Bengal, the war with Hyder Ali, and other Indian difficulties.” While Burke and the committee focused their attention on these matters, a second ‘secret’ committee was formed to assess the same issues. Both committee reports were written by Burke and lead to the reassurance to the Indian princes that Britain would not wage war on them and the demand for the EIC to recall Hastings. This is Burke’s first call for real, significant change of the imperial practices. When addressing the whole House of Commons in regards to the committee’s report, Burke would describe the Indian issue as one that “began ‘in commerce’ but ‘ended in empire.’”

On February 28, 1785 he made his great speech on The Nabob of Arcot's Debts, where he condemned the damage he believed the East India Company had done to India. In the province of the Carnatic the Indians had constructed a system of reservoirs to make the soil fertile in a naturally dry region, and centred their society on the husbandry of water. Burke held that the advent of British dominion, and in particular the conduct of the East India Company had destroyed much that was good in these traditions and that, as a consequence of this, and the lack of new customs to replace them, the Indians were suffering. He set about establishing a set of British expectations, whose moral foundation would, in his opinion, warrant the empire.

On April 4, 1786 Burke presented the Commons with the Article of Charge of High Crimes and Misdemeanors against Warren Hastings, the former Governor General of Bengal. The trial, which did not begin until February 14, 1788, would be the “first major public discursive event of its kind in England,” bringing the morality and duty of imperialism to the forefront of the public’s perception. Burke was already known for his eloquent rhetorical skills and his involvement in the trial only enhanced its popularity and significance. For the members of London’s fashionable society, the trial was a spectacle , and was not centered around Hastings’ alleged misconduct and crimes as had been Burke’s intent. Burke's indictment, fuelled by emotional indignation, called Hastings the 'captain-general of iniquity'; who never dined without 'creating a famine'; his heart was 'gangrened to the core' and he resembled both a 'spider of Hell' and a 'ravenous vulture devouring the carcases of the dead'. The indictment was such a philippic that, whereas it had previously seemed that Hastings would be found guilty, it actually provoked public sympathy; however, although Hastings was acquitted, the trial served to establish the principle that the Empire was a moral undertaking rather than a wholesale looting by either the East India Company or its servants.

Burke did not initially condemn the French Revolution. In a letter of 9 August 1789, Burke wrote: "England gazing with astonishment at a French struggle for Liberty and not knowing whether to blame or to applaud! The thing indeed, though I thought I saw something like it in progress for several years, has still something in it paradoxical and Mysterious. The spirit it is impossible not to admire; but the old Parisian ferocity has broken out in a shocking manner". The events of 5–6 October 1789, in which a mob of Parisian women marched on Versailles to compel King Louis XVI to return to Paris, turned Burke against it. In a letter to his son Richard on 10 October he said: "This day I heard from Laurence who has sent me papers confirming the portentous state of France — where the Elements which compose Human Society seem all to be dissolved, and a world of Monsters to be produced in the place of it — where Mirabeau presides as the Grand Anarch; and the late Grand Monarch makes a figure as ridiculous as pitiable". On 4 November Charles-Jean-François Depont wrote to Burke, requesting that he endorse the Revolution. Burke replied that any critical language of it by him should be taken "as no more than the expression of doubt" but added: "You may have subverted Monarchy, but not recover'd freedom". In the same month he described France as "a country undone". Burke's first public condemnation of the Revolution occurred on the debate in Parliament on the Army Estimates on 9 February 1790, provoked by praise of the Revolution by Pitt and Fox.

In January 1790 Burke read Dr. Richard Price's sermon of 4 November 1789 to the Revolution Society, called A Discourse On the Love of our Country. The Revolution Society was founded to commemorate the Glorious Revolution of 1688. In this sermon Price espoused the philosophy of universal "rights of men". Price argued that love of our country "does not imply any conviction of the superior value of it to other countries, or any particular preference of its laws and constitution of government". Instead, Englishmen should see themselves "more as citizens of the world than as members of any particular community". The debate between Price and Burke was "the classic moment at which two fundamentally different conceptions of national identity were presented to the English public". Price claimed that the principles of the Glorious Revolution included "the right to choose our own governors, to cashier them for misconduct, and to frame a government for ourselves". Immediately after reading Price's sermon, Burke wrote a draft of what would eventually become the Reflections on the Revolution in France. On 13 February 1790 there appeared a notice in the press that Burke would shortly publish a pamphlet on the Revolution and its British supporters, however he spent the year revising and expanding it. On 1 November he finally published the Reflections and it was an immediate best-seller. Priced at five shillings, it was more expensive than most political pamphlets but by the end of 1790 it had gone through ten printings and sold approximately 17,500 copies. A French translation appeared on 29 November and on 30 November the translator, Pierre-Gaëton Dupont, wrote to Burke saying 2,500 copies had already been sold. The French translation ran to ten printings by June 1791.

What the Glorious Revolution had meant was important to Burke and his contemporaries, as it had been for the last one hundred years in British politics. In the Reflections, Burke argued against Price's interpretation of the Glorious Revolution and instead gave a classic Whig defence of it. Burke argued against the idea of abstract, metaphysical rights of men and instead advocated national tradition. Burke put forward that "We fear God, we look up with awe to kings; with affection to parliaments; with duty to magistrates; with reverence to priests; and with respect to nobility. Why? Because when such ideas are brought before our minds, it is natural to be so affected". Burke defended prejudice on the grounds that it is "the general bank and capital of nations, and of ages" and superior to individual reason, which is small in comparison. "Prejudice", Burke claimed, "is of ready application in the emergency; it previously engages the mind in a steady course of wisdom and virtue, and does not leave the man hesitating in the moment of decision, skeptical, puzzled, and unresolved. Prejudice renders a man's virtue his habit". Burke criticised social contract theory by claiming that society is indeed a contract, but "a partnership not only between those who are living, but between those who are living, those who are dead, and those who are to be born". The most famous passage of the Reflections was his description of the events of 5–6 October 1789 and Marie Antoinette's part in them. Burke's account differs little from modern historians who have used primary sources. His use of flowery language to describe it, however, provoked both praise and criticism. Philip Francis wrote to Burke saying that what he wrote of Marie Antoinette was "pure foppery". Edward Gibbon however reacted differently: "I adore his chivalry". Burke was informed by an Englishman who had talked with the Duchesse de Biron that when Marie Antoinette was reading the passage she burst into tears and took considerable time to finish reading it. Price had rejoiced that the French king had been "led in triumph" during the October Days but to Burke this symbolised the opposing revolutionary sentiment of the Jacobins and the natural sentiments of those like himself who regarded the ungallant assault on Marie Antoinette with horror, as a cowardly attack on a defenceless woman.

Louis XVI translated the Reflections "from end to end" into French. Fellow Whig MPs Richard Sheridan and Charles James Fox disagreed with Burke and split with him. Fox thought the Reflections to be "in very bad taste" and "favouring Tory principles". Other Whigs such as the Duke of Portland and Earl Fitzwilliam privately agreed with Burke but did not wish for a public breach with their Whig colleagues. Burke wrote on 29 November 1790: "I have received from the Duke of Portland, Lord Fitzwilliam, the Duke of Devonshire, Lord John Cavendish Montagu and a long et cetera of the old Stamina of the Whiggs a most full approbation of the principles of that work and a kind indulgence to the execution". The Duke of Portland said in 1791 that when anyone criticised the Reflections to him he informed them that he had recommended the book to his sons as containing the true Whig creed. King George III at a levee on 3 February 1791 said to Burke: "I know that there is no Man who calls himself a Gentleman that must not think himself obliged to you, for you have supported the cause of the Gentlemen".

Burke's Reflections sparked a pamphlet war. Thomas Paine penned The Rights of Man in 1791 as a response to Burke; Mary Wollstonecraft published A Vindication of the Rights of Men and James Mackintosh wrote Vindiciae Gallicae. Mackintosh was the first to see the Reflections as "the manifesto of a Counter Revolution". Mackintosh would later come to agree with Burke's views, remarking in December 1796 after meeting him, that Burke was "minutely and accurately informed, to a wonderful exactness, with respect to every fact relating to the French Revolution". Mackintosh later said: "Burke was one of the first thinkers as well as one of the greatest orators of his time. He is without parallel in any age, excepting perhaps Lord Bacon and Cicero; and his works contain an ampler store of political and moral wisdom than can be found in any other writer whatever".

In November 1790 a member of the National Assembly of France, François-Louis-Thibault de Menonville, wrote to Burke, praising the Reflections and requesting more "very refreshing mental food" which he could publish. This Burke did in April 1791 when he published A Letter to a Member of the National Assembly. Burke called for external forces to reverse the Revolution and included an attack on the late French philosopher Jean-Jacques Rousseau, as a personality cult had developed in revolutionary France. Although Burke conceded that Rousseau sometimes shows "a considerable insight into human nature" he was mostly critical. Although he did not meet Rousseau on his visit to Britain in 1766-7 he was a friend of David Hume, with whom Rousseau had stayed. Burke said Rousseau "entertained no principle either to influence of his heart, or to guide his understanding, but vanity", which he "was possessed to a degree little short of madness". He also cited Rousseau's Confessions as evidence that Rousseau had a life of "obscure and vulgar vices" that was not "chequered, or spotted here and there, with virtues, or even distinguished by a single good action". Burke contrasted Rousseau's theory of universal benevolence and his sending his children to a foundling hospital: "a lover of his kind, but a hater of his kindred".

These events, and the disagreements which arose regarding them within the Whig party, led to its breakup and to the rupture of Burke's friendship with Fox. In debate in Parliament on Britain's relations with Russia, Fox praised the principles of the Revolution, though Burke was not able to reply at this time as he was "overpowered by continued cries of question from his own side of the House". When Parliament was debating the Quebec Bill for a constitution for Canada, Fox praised the Revolution and criticised some of Burke's arguments, such as hereditary power. On 6 May 1791, during another debate in Parliament on the Quebec Bill, Burke used the opportunity to answer Fox and condemn the new French Constitution and "the horrible consequences flowing from the French idea of the rights of man". Burke asserted that those ideas were the antithesis of both the British and the American constitutions. Burke was interrupted, and Fox intervened to say that Burke should be allowed to carry on with his speech. However a vote of censure was moved against Burke for noticing the affairs of France, which was moved by Lord Sheffield and seconded by Fox. Pitt made a speech praising Burke, and Fox made a speech both rebuking and complimenting Burke. He questioned the sincerity of Burke, who seemed to have forgotten the lessons he had taught him, quoting from Burke's speeches of fourteen and fifteen years before. Burke replied:

It certainly was indiscreet at any period, but especially at his time of life, to parade enemies, or give his friends occasion to desert him; yet if his firm and steady adherence to the British constitution placed him in such a dilemma, he would risk all, and, as public duty and public experience taught him, with his last words exclaim, "Fly from the French Constitution".

At this point Fox whispered that there was "no loss of friendship". "I regret to say there is", Burke said, "I have indeed made a great sacrifice; I have done my duty though I have lost my friend. There is something in the detested French constitution that envenoms every thing it touches". This provoked a reply from Fox, yet he was unable to give his speech for some time since he was overcome with tears and emotion, he appealed to Burke to remember their inalienable friendship but also repeated his criticisms of Burke and uttered "unusually bitter sarcasms". This only aggravated the rupture between the two men. Burke demonstrated his separation from the party on 5 June 1791 by writing to Fitzwilliam, declining money from him.

Burke was dismayed that some Whigs, instead of reaffirming the principles of the Whig party he laid out in the Reflections, had rejected them in favour of "French principles" and criticised Burke for abandoning Whig principles. Burke wanted to demonstrate his fidelity to Whig principles and feared that acquiescence to Fox and his followers would allow the Whig party to become a vehicle for Jacobinism. Burke knew that many members of the Whig party did not share Fox's views and wanted to provoke them into condemning the French Revolution. Burke wrote that he wanted to represent the whole Whig party "as tolerating, and by a toleration, countenancing those proceedings" so that he could "stimulate them to a public declaration of what every one of their acquaintance privately knows to be...their sentiments". Therefore on 3 August 1791 Burke published his Appeal from the New to the Old Whigs, in which he renewed his criticism of the radical revolutionary programmes inspired by the French Revolution and attacked the Whigs who supported them as holding principles contrary to those traditionally held by the Whig party. Burke owned two copies of what has been called "that practical compendium of Whig political theory", The Tryal of Dr. Henry Sacheverell (1710). Burke wrote of the trial: "It rarely happens to a party to have the opportunity of a clear, authentic, recorded, declaration of their political tenets upon the subject of a great constitutional event like that of the [Glorious] Revolution". Burke provided quotations from Paine's Rights of Man to demonstrate what the New Whigs believed. Burke's belief that Foxite principles corresponded to Paine's was genuine. Finally, Burke denied that a majority of "the people" had, or ought to have, the final say in politics and alter society at their pleasure. People had rights but also duties, and these duties were not voluntary. Also, the people could not overthrow morality which is derived from God.

Although Whig grandees like Portland and Fitzwilliam privately agreed with Burke's Appeal, they wished he had used more moderate language. Fitzwilliam saw the Appeal as containing "the doctrines I have sworn by, long and long since". Francis Basset, a backbench Whig MP, wrote to Burke: "...though for reasons which I will not now detail I did not then deliver my sentiments, I most perfectly differ from Mr Fox & from the great Body of opposition on the French Revolution". Burke sent a copy of the Appeal to the King and the King requested a friend to communicate to Burke that he had read it "with great Satisfaction". Burke wrote of its reception: "Not one word from one of our party. They are secretly galled. They agree with me to a title; but they dare not speak out for fear of hurting Fox. ... They leave me to myself; they see that I can do myself justice". Charles Burney viewed it as "a most admirable book — the best & most useful on political subjects that I have ever seen" but believed the differences in the Whig party between Burke and Fox should not be publicly aired. Eventually most of the Whigs sided with Burke and voted their support for the conservative government of Pitt, which, in response to France's declaration of war against Britain, declared war on the revolutionary government of France in 1793.

In December 1791 Burke sent government ministers his Thoughts on French Affairs where he put forward three main points: no counter revolution in France would come about by purely domestic causes; the longer the revolutionary government exists the stronger it becomes; and the revolutionary government's interest and aim is to disturb all the other governments of Europe. Burke, as a Whig, did not wish to see an absolute monarchy again in France after the extirpation of Jacobinism. Writing to an émigré in 1791, Burke expressed his views against a restoration of the ancien régime.

Burke delivered a speech on the debate of the Aliens Bill on 28 December 1792. He supported the Bill as it would exclude "murderous atheists, who would pull down church and state; religion and God; morality and happiness". The peroration included a reference to a French order for 3,000 daggers. Burke revealed a dagger he had concealed in his coat and threw it to the floor: "This is what you are to gain by an alliance with France". Burke picked up the dagger and continued:

When they smile, I see blood trickling down their faces; I see their insidious purposes; I see that the object of all their cajoling is — blood! I now warn my countrymen to beware of these execrable philosophers, whose only object it is to destroy every thing that is good here, and to establish immorality and murder by precept and example—'Hic niger est hunc tu Romane caveto' ['Such a man is evil; beware of him, Roman'. Horace, Satires I. 4. 85.].

Burke supported the war against revolutionary France, seeing Britain as fighting on the side of the royalists and émigres in a civil war, rather than fighting against the whole nation of France. Burke also supported the royalist uprising in La Vendée, describing it on 4 November 1793 in a letter to William Windham, as "the sole affair I have much heart in". Burke wrote to Henry Dundas on 7 October urging him to send reinforcements there as he viewed it as the only theatre in the war which might lead to a march on Paris. However Dundas did not follow Burke's advice. Burke believed the government was not taking the uprising seriously enough, a view reinforced by a letter he had received from the Comte d'Artois, dated 23 October, requesting that he intercede on behalf of the royalists to the government. Burke was forced to reply on 6 November: "I am not in His Majesty's Service; or at all consulted in his Affairs". Burke published his Remarks on the Policy of the Allies with Respect to France, begun in October, where he said: "I am sure every thing has shewn us that in this war with France, one Frenchman is worth twenty foreigners. La Vendee is a proof of this".

On 20 June 1794 Burke received a vote of thanks from the Commons for his services in the Hastings trial and immediately resigned his seat, being replaced by his son Richard. However a terrible blow fell upon Burke in the loss of Richard in August 1794, to whom he was tenderly attached, and in whom he saw signs of promise. The King, whose favour he had gained by his attitude on the French Revolution, wished to make him Lord Beaconsfield, but the death of his son had deprived such an honour of all its attractions, and the only reward he would accept was a pension of £2,500. This pension was attacked by the Duke of Bedford and the Earl of Lauderdale, to whom Burke replied in the Letter to a Noble Lord (1796). Burke wrote: "It cannot at this time be too often repeated; line upon line; precept upon precept; until it comes into the currency of a proverb, To innovate is not to reform". He argued that he was rewarded on merit but the Duke of Bedford received his rewards from inheritance alone, his ancestor being the original pensioner: "Mine was from a mild and benevolent sovereign; his from Henry the Eighth". Burke also hinted at what would happen to such people if their revolutionary ideas were implemented, and included a description of the British constitution.

Burke's last publications were the Letters on a Regicide Peace (October 1796), called forth by the Pitt government's negotiations for peace with France. Burke regarded this as appeasement, injurious to national dignity and honour. In the Second Letter, Burke wrote of the revolutionary French government: "Individuality is left out of their scheme of government. The state is all in all. Everything is referred to the production of force; afterwards, everything is trusted to the use of it. It is military in its principle, in its maxims, in its spirit, and in all its movements. The state has dominion and conquest for its sole objects — dominion over minds by proselytism, over bodies by arms". This has been seen as the first time someone explained the modern totalitarian state. Burke regarded the war with France as ideological,  gainst an "armed doctrine". He wished that France would not be partitioned due to the effect this would have on the balance of power in Europe, and that the war was not against France but against the revolutionaries governing her. Burke said: "It is not France extending a foreign empire over other nations: it is a sect aiming at universal empire, and beginning with the conquest of France".

In November 1795 there was a debate in Parliament on the high price of corn and Burke wrote a memorandum to Pitt on the subject. In December Samuel Whitbread MP introduced a bill giving magistrates the power to fix minimum wages and Fox said he would vote for it. This debate probably led Burke to editing his memorandum as there appeared a notice that Burke would soon publish a letter on the subject to the Secretary of the Board of Agriculture (Arthur Young), but he failed to complete it. These fragments were inserted into the memorandum after his death and published posthumously in 1800 as Thoughts and Details on Scarcity. In it, Burke expounded "some of the doctrines of political economists bearing upon agriculture as a trade". Burke criticised policies such as maximum prices and state regulation of wages, and set out what the limits of government should be. The economist Adam Smith remarked that Burke was "the only man I ever knew who thinks on economic subjects exactly as I do, without any previous communications having passed between us".

Writing to a friend in May 1795, Burke surveyed the causes of discontent: "I think I can hardly overrate the malignity of the principles of Protestant ascendency, as they affect Ireland; or of Indianism, as they affect these countries, and as they affect Asia; or of Jacobinism, as they affect all Europe, and the state of human society itself. The last is the greatest evil". However by March 1796 Burke had changed his mind: "Our Government and our Laws are beset by two different Enemies, which are sapping its foundations, Indianism, and Jacobinism. In some Cases they act separately, in some they act in conjunction: But of this I am sure; that the first is the worst by far, and the hardest to deal with; and for this amongst other reasons, that it weakens discredits, and ruins that force, which ought to be employed with the greatest Credit and Energy against the other; and that it furnishes Jacobinism with its strongest arms against all formal Government".

For more than a year before his death Burke knew that his stomach was "irrecoverably ruind". After hearing that Burke was nearing death, Fox wrote to Mrs. Burke enquiring after him. Fox received the reply the next day:

Mrs. Burke presents her compliments to Mr. Fox, and thanks him for his obliging inquiries. Mrs. Burke communicated his letter to Mr. Burke, and by his desire has to inform Mr. Fox that it has cost Mr. Burke the most heart-felt pain to obey the stern voice of his duty in rending asunder a long friendship, but that he deemed this sacrifice necessary; that his principles continue the same; and that in whatever of life may yet remain to him, he conceives that he must live for others and not for himself. Mr. Burke is convinced that the principles which he has endeavoured to maintain are necessary to the welfare and dignity of his country, and that these principles can be enforced only by the general persuasion of his sincerity.

Burke died in Beaconsfield, Buckinghamshire on 9 July 1797. He was buried in Beaconsfield alongside his son and brother. His wife survived him by nearly fifteen years.