Walter Rudolf Hess (March 17, 1881 – August 12, 1973) was a Swiss physiologist who won the Nobel Prize in Physiology or Medicine in 1949 for mapping the areas of the brain involved in the control of internal organs. He shared the prize with Egas Moniz.

Hess was born in Frauenfeld. He received his medical degree from the University of Zürich in 1906 and trained as surgeon and ophthalmologist. In 1912, he left his lucrative private practice as an ophthalmologist and went into research. His main interests were the regulation of blood flow and respiration. As an outgrowth of these research interests, he began mapping the parts of the diencephalon that control the internal organs. From 1917 to 1951, he served as professor and director of the Department of the Physiological Institute at the University of Zürich. Hess died in Locarno, Switzerland.