René of Châlon (5 February 1519 – 15 July 1544), also known as Renatus of Châlon, was a Prince of Orange and stadtholder of Holland, Zeeland, Utrecht and Gelre.

René was born in Breda, the only son of Count Henry III of Nassau - Breda and Claudia of Châlon. Claudia's brother, Philibert of Châlon, was the last Prince of Orange from the house of Châlon. When Philibert died in 1530, René inherited the Princedom of Orange on condition that he used the name and coat of arms of the Châlon - Orange family. History knows him therefore as René of Châlon instead of as "René of Nassau - Breda."

René of Châlon married Anna of Lorraine (1522 - 1568) on 20 August 1540 at Bar - le - Duc. They had only one child, a daughter named Maria, who lived only 3 weeks and was buried in the "Grote Kerk" in Breda.

In 1544, René took part in the siege of St. Dizier in the service of Emperor Charles V. He was mortally wounded in battle and died with the Emperor attending at his bedside. René was buried in Grote Kerk in Breda, near the resting place of his short lived daughter. A commemorative cenotaph stands in the church of St. Etienne in Bar - le - Duc.

René's cousin William of Nassau - Dillenburg (better known as "William the Silent") inherited all of René’s lands. William added the name of Orange to his own paternal dignities and and thus became the founder of the House of Orange - Nassau.