Harry Sinclair Lewis (February 7, 1885 – January 10, 1951) was an American novelist, short - story writer, and playwright. In 1930, he became the first writer from the United States to be awarded the Nobel Prize in Literature, "for his vigorous and graphic art of description and his ability to create, with wit and humor, new types of characters." His works are known for their insightful and critical views of American society and capitalist values, as well as for their strong characterizations of modern working women. He has been honored by the U.S. Postal Service with a Great Americans series postage stamp.

Born in the village of Sauk Centre, Minnesota, Lewis began reading books at a young age and kept a diary. He had two siblings, Fred (born 1875) and Claude (born 1878). His father, Edwin J. Lewis, was a physician and a stern disciplinarian who had difficulty relating to his sensitive, unathletic third son. Lewis's mother, Emma Kermott Lewis, died in 1891. The following year, Edwin Lewis married Isabel Warner, whose company young Lewis apparently enjoyed. Throughout his lonely boyhood, the ungainly Lewis — tall, extremely thin, stricken with acne and somewhat popeyed — had trouble gaining friends and pined after various local girls. At the age of 13 he unsuccessfully ran away from home, wanting to become a drummer boy in the Spanish - American War.

In late 1902 Lewis left home for a year at Oberlin Academy (the then - preparatory department of Oberlin College) to qualify for acceptance by Yale University. While at Oberlin, he developed a religious enthusiasm that waxed and waned for much of his remaining teenage years. He entered Yale in 1903 but did not receive his bachelor's degree until 1908, having taken time off to work at Helicon Home Colony, Upton Sinclair's cooperative - living colony in Englewood, New Jersey, and to travel to Panama. Lewis's unprepossessing looks, "fresh" country manners and seemingly self - important loquacity made it difficult for him to win and keep friends at Oberlin and Yale. He did initiate a few relatively long lived friendships among students and professors, some of whom recognized his promise as a writer.

Lewis's first published book was Hike and the Aeroplane, a Tom Swift style potboiler that appeared in 1912 under the pseudonym Tom Graham.

Sinclair Lewis's first serious novel, Our Mr. Wrenn: The Romantic Adventures of a Gentle Man, appeared in 1914, followed by The Trail of the Hawk: A Comedy of the Seriousness of Life (1915) and The Job (1917). That same year also saw the publication of another potboiler, The Innocents: A Story for Lovers, an expanded version of a serial story that had originally appeared in Woman's Home Companion. Free Air, another refurbished serial story, was published in 1919.

In 1914 Lewis married Grace Livingston Hegger, an editor at Vogue magazine. They had one son, Wells Lewis (1917 – 1944), named after British author H.G. Wells. Wells Lewis was killed while serving in the military in World War II.

Lewis divorced Grace in 1925. On May 14, 1928, he married Dorothy Thompson, a political newspaper columnist. Later in 1928, he and Dorothy purchased a second home in rural Vermont. They had a son, Michael Lewis, in 1930. Their marriage had virtually ended by 1937, and they divorced in 1942. Michael Lewis became an actor, and died in 1975 at age 44.

Upon moving to Washington, D.C., Lewis devoted himself to writing. As early as 1916, he began taking notes for a realistic novel about small town life. Work on that novel continued through mid 1920, when he completed Main Street, which was published on October 23, 1920. As his biographer Mark Schorer wrote, the phenomenal success of Main Street "was the most sensational event in twentieth century American publishing history." Based on sales of his prior books, Lewis's most optimistic projection was a sale of 25,000 copies. In the first six months of 1921, Main Street sold 180,000 copies, and within a few years, sales were estimated at two million. According to Richard Lingeman, "Main Street earned Sinclair Lewis about three million current [2002] dollars".

Lewis followed up this first great success with Babbitt (1922), a novel that satirized the American commercial culture and boosterism. The story was set in the fictional Midwestern town of Zenith, Winnemac, a setting to which Lewis would return in future novels, including Gideon Planish and Dodsworth.

Lewis continued his success in the 1920s with Arrowsmith (1925), a novel about the challenges faced by an idealistic doctor. It was awarded the Pulitzer Prize (which Lewis refused). Adapted as a 1931 Hollywood film directed by John Ford and starring Ronald Colman, it was nominated for four Academy Awards.

Next Lewis published Elmer Gantry (1927), which depicted an evangelical minister as deeply hypocritical. The novel was denounced by many religious leaders and banned in some U.S. cities. Adapted for the screen more than a generation later, the novel was the basis of the 1960 movie starring Burt Lancaster, who earned a Best Actor Oscar for his performance.

Lewis closed out the decade with Dodsworth (1929), a novel about the most affluent and successful members of American society. He portrayed them as leading essentially pointless lives in spite of great wealth and advantages. The book was adapted for the Broadway stage in 1934 by Sidney Howard, who also wrote the screenplay for the 1936 film version. Directed by William Wyler and a great success at the time, the film is still highly regarded. In 1990, it was selected for preservation in the United States National Film Registry, and in 2005 Time magazine named it one of the "100 Best Movies" of the past 80 years.

During the late 1920s and 1930s, Lewis wrote many short stories for a variety of magazines and publications. "Little Bear Bongo" (1936), a tale about a bear cub who wanted to escape the circus in search of a better life in the real world, was published in Cosmopolitan magazine. The story was acquired by Walt Disney Pictures in 1940 for a possible feature film. World War II sidetracked those plans until 1947. Disney used the story (now titled "Bongo") as part of its feature Fun and Fancy Free.

After an alcoholic binge in 1937, Lewis checked into the Austen Riggs Center, a psychiatric hospital in Stockbridge, Massachusetts, for treatment. His doctors gave Lewis a blunt assessment that he needed to decide "whether he was going to live without alcohol or die by it, one or the other." Lewis checked out after 10 days, lacking, one of his physicians wrote to a colleague, any "fundamental understanding of his problem."

In 1930, Lewis won the Nobel Prize in Literature, the first writer from the United States to receive the award. In the Swedish Academy's presentation speech, special attention was paid to Babbitt. In his Nobel Lecture, Lewis praised Theodore Dreiser, Willa Cather, Ernest Hemingway, and other contemporaries, but also lamented that "in America most of us — not readers alone, but even writers — are still afraid of any literature which is not a glorification of everything American, a glorification of our faults as well as our virtues," and that America is "the most contradictory, the most depressing, the most stirring, of any land in the world today." He also offered a profound criticism of the American literary establishment: "Our American professors like their literature clear and cold and pure and very dead."

Kingsblood Royal (1947) is set in the fictional city Grand Republic, Minnesota, an enlarged and updated version of Zenith. Based on the Sweet Affair in Chicago, in which an African - American doctor was denied the chance to purchase a house in a "white" section of the city, Kingsblood Royal was a powerful and very early contribution to the civil rights movement.

Lewis died in Rome on January 10, 1951, aged 65, from advanced alcoholism. His cremated remains were buried in Sauk Centre. A final novel, World So Wide (1951), was published posthumously.

William Shirer, a friend and admirer of Lewis, disputes accounts that Lewis died of alcoholism per se. He reported that Lewis had a heart attack and that his doctors advised him to stop drinking if he wanted to live. Lewis did not, and perhaps could not, stop; he died when his heart stopped.

In summing up Lewis' career, Shirer concludes, "It has become rather commonplace for so-called literary critics to write off Sinclair Lewis as a novelist. Compared to... Fitzgerald, Hemingway, Dos Passos, and Faulkner... Lewis lacked style. Yet his impact on modern American life... was greater than all of the other four writers together."

In The New Yorker, Wolcott Gibbs once published a spoof of Lewis' novel Cass Timberlane which he titled "Shad Ampersand."