He was born in the village of Kobiele Wielkie, near Radomsko, as one of nine children to Józef Rejment, an organist. He spent his childhood in Tuszyn near Łódź, to which his father had moved in order to work at a richer church parish. Reymont was defiantly stubborn; after a few years of education in the local school he was sent by his father to Warsaw into the care of his eldest sister and her husband to teach him his vocation. In 1885, after passing his examinations and presenting "a tail - coat, well - made", he was given the title of journeyman tailor — his only formal certificate of education.

To his family's annoyance he did not work a single day as a tailor. Instead he first ran away to work in a travelling provincial theatre and then returned in the summer to Warsaw for the "garden theatres". Without a penny to his name he then returned to Tuszyn after a year and, thanks to his father's connections, took up employment as a gateman at a railway crossing near Koluszki for 16 rubles a month. He escaped twice more: in 1888 to Paris and London as a medium with a German spiritualist, and then again to a theatre troupe. After his lack of success (he was not a talented actor), he returned home again. Reymont also stayed for a time in Krosnowa near Lipce and for a time considered joining the Pauline Order in Częstochowa. He also lived in Kołaczkowo, where he bought a mansion.

When his Korespondencje (Correspondence) from Rogowo, Koluszki and Skierniewice was accepted for publication by Głos (The Voice) in Warsaw in 1892, he returned to Warsaw once more, clutching a group of unpublished short stories along with a few rubles in his pocket. Reymont then visited the editorial offices of various newspapers and magazines, and eventually met other writers who became interested in his talent. On a Mr. Świętochowski's advice, he went on a pilgrimage to Częstochowa in 1894 and wrote a report on his experience there. The report remains a classic example of travel writing.

Rejmont proceeded to send his short stories to different magazines, and, encouraged by good reviews, decided to write novels: Komediantka (The Deceiver) (1895) and Fermenty (Ferments) (1896). No longer poor, he would soon satisfy his passion for travel, visiting Berlin, London, Paris, Italy. Then, he spent a few months in Łódź collecting material for a new novel ordered by the Kurier Codzienny (The Daily Courier) from Warsaw. The earnings from this book — Ziemia obiecana (The Promised Land) (1897) — enabled him to go on his next trip to France where he socialized with other exiled Poles (Jan Lorentowicz, Żeromski, Przybyszewski, Rydel, etc.).

His earnings did not allow for this kind of life of travel. However, in 1900 he was awarded 40,000 rubles in compensation from the Warsaw - Vienna Railway after an accident in which Reymont as a passenger was severely injured. During the treatment he was looked after by Aurelia Szacnajder Szabłowska, whom he married in 1902, having first paid for the annulment of her earlier marriage. Thanks to her discipline, he restrained his travel mania somewhat, but never gave up either his stays in France (where he partly wrote Chłopi between 1901 and 1908) or in Zakopane. Rejmont also journeyed to the United States in 1919 at the (Polish) government's expense. Despite his ambitions to become a landowner, which led to an unsuccessful attempt to manage an estate he bought in 1912 near Sieradz, the life of the land proved not to be for him. He would later buy Kołaczkowo Gmina Kołaczkowo near Poznań in 1920, but still spent his winters in Warsaw or France.

In November 1924 he was awarded the Nobel Prize for Literature over rivals Thomas Mann, Maxim Gorky and Thomas Hardy. Public opinion in Poland supported the Nobel for Stefan Żeromski, but the prize went to the author of Chłopi. Żeromski, considered a better candidate, was reportedly refused for his allegedly anti - German sentiments. However, Reymont could not take part in the award ceremony in Sweden due to a heart illness. The award and the check for 116,718 Swedish kroner were sent to Reymont in France, where he was being treated.

In 1925, somewhat recovered, he went to a farmers' meeting in Wierzchosławice near Kraków, where Wincenty Witos welcomed him as a member of PSL "Piast" (the Polish Peasant Party) and praised his writing skills. Soon after that event, Reymont's health deteriorated. He died in Warsaw in December 1925 and was buried in the Powązki Cemetery. The urn holding his heart was laid in a pillar of the Holy Cross Church in Warsaw.

Reymont's literary output includes about 30 extensive volumes of prose. There are works of reportage: Pielgrzymka do Jasnej Góry (Pilgrimage to Jasna Góra) (1894), Z ziemi chełmskiej (From the Chełm Lands) (1910 – about the persecutions of the Uniates), Z konstytucyjnych dni (From the Days of the Constitution) (about the revolution of 1905) and some sketches from the collection Za frontem (Beyond the Front) (1919). There are numerous short stories on life in the theatre, village life or work on the railway: "Śmierć" ("Death") (1893), "Suka" ("Bitch") (1894), "Przy robocie" ("At Work") and "W porębie" ("In the Clearing") (1895), "Tomek Baran" (1897), "Sprawiedliwie" ("Justly") (1899) and a sketch for a novel Marzyciel (Dreamer) (1908). Then there are the novels: Komediantka, Fermenty, Ziemia obiecana, Chłopi, Wampir (The Vampire) (1911), which was sceptically received by the critics, and a trilogy written in the years 1911 – 1917: Rok 1794 (1794) (Ostatni Sejm Rzeczypospolitej, Nil desperandum andInsurekcja) (The Last Parliament of the Commonwealth, Nil desperandum and Insurrection).

Critics admit a number of similarities between Reymont and the Naturalists, but they stress that this was not a "borrowed" Naturalism, but rather a record of life as experienced by the writer himself. Moreover, Reymont never formulated an aesthetic of his writing. In that, he resembled other Polish autodidacts such as Mikołaj Rej and Aleksander Fredro. With little higher education and unable to read any foreign language, Reymont realized that it was his knowledge of grounded reality, not literary theory, that was his strong suit.

His novel Komendiantka paints the drama of a rebellious girl from the provinces who joins a traveling theater troupe and finds, instead of escape from the mendacity of her native surroundings, a nest of intrigue and sham. In Fermenty, a sequel to Komediantka, the heroine, rescued after an unsuccessful suicide attempt, returns to her family and accepts the burden of existence. Aware that dreams and ideas do not come true, she marries a nouveau riche who is in love with her.

Ziemia Obiecana (The Promised Land), possibly Reymont's best known novel, is a social panorama of the city of Łódź during the industrial revolution, full of dramatic detail, presented as an arena of the struggle for survival. In the novel, the city destroys those who accept the rules of the "rat race", as well as those who do not. The moral gangrene affects equally the three main characters, a German, a Jew, and a Pole. This dark vision of cynicism, illustrating the bestial qualities of men and the law of the jungle, where ethics, noble ideas and holy feelings turn against those who believe in them, are, as the author intended, at the same time a denunciation of industrialisation and urbanisation.

Ziemia Obiecana has been translated into at least 15 languages and two film adaptations — one in 1927, directed by A. Węgierski and A. Hertz; and the other, in 1975, directed by Andrzej Wajda.

In Chłopi, Reymont created a more complete and suggestive picture of country life than any other Polish writer. The novel impresses the reader with its authenticity of the material reality, customs, behaviour and spiritual culture of the people. It is even more authentic in that it is written in the local dialect. Not only did Reymont use dialect in dialogues but also in narration, creating a kind of a universal language of Polish peasants. Thanks to this, he presents the colourful reality of the "spoken" culture of the people better than any other author. He set the action of the novel in Lipce, a real village which he came to know during his work on the railway near Skierniewice, and restricted the time of events to ten months in the unspecified "now" of the nineteenth century. It is not history that determines the rhythm of country life, but the "unspecified time" of eternal returns. The composition of the novel astonishes the reader with its strict simplicity and functionality. What is easier than writing a novel about village life, restricting its plot to one year and one place? The titles of the various volumes signal a tetralogy in one vegetational cycle, which regulates the eternal and repeatable rhythm of village life. Parallel to that rhythm is a calendar of religion and customs, also repeatable. In such boundaries Reymont placed a colourful country community with sharply drawn individual portraits. The repertoire of human experience and the richness of spiritual life, which can be compared with the repertoire of Biblical books and Greek myths, has no doctrinal ideas or didactic exemplifications. The author of Chłopi does not believe in doctrines, but rather in his own knowledge of life, the mentality of the people described, and his sense of reality. It is easy to point to moments of Naturalism (e.g. some erotic elements) or to illustrative motives characteristic of Symbolism. It is equally easy to prove the Realistic values of the novel. None of the "isms" however, would be enough to describe it. The novel was filmed twice (directed by E. Modzelewski in 1922 and by J. Rybkowski in 1973) and has been translated into at least 27 languages.

Reymont's last book, Bunt (Revolt), serialized 1922 and published in book form in 1924, describes a revolt by animals which take over their farm in order to introduce "equality". The revolt quickly degenerates into abuse and bloody terror.

The story was a metaphor for the Bolshevik Revolution of 1917 and was banned 1945 – 1989 in communist Poland, along with George Orwell's similar novella, Animal Farm (published in Britain in 1945). It is unknown whether Orwell knew of Reymont's Revolt of over two decades earlier. Reymont's novel was reprinted in Poland in 2004.