La Santé Prison (French: Maison d'arrêt de la Santé or Paris - La Santé) is a prison operated by the Ministry of Justice located in the 14th arrondissement of Paris, France. It is one of the most famous prisons in France, with both VIP and high security wings.

La Santé is one of the three main prisons of the Paris area, the Fleury - Mérogis Prison (Europe's largest prison) and the Fresnes Prison, both located in the southern suburbs, being the other two.

The architect Vaudremer built the prison, which was inaugurated on 20 August 1867.

During World War II, the prison was used to hold both common criminals as well as opponents of the German occupation. On Bastille Day in 1944, as Allied forces were approaching the city, the prisoners revolted, an insurrection that was put down with great brutality and loss of life by the Vichy Milice.

The prison features a hub - and - spoke design similar to that which had been previously implemented in the construction of Eastern State Penitentiary in Philadelphia, Pennsylvania, USA.

In 2000, the head doctor of the prison, Veronique Vasseur, published a book in which she denounced the very bad conditions of imprisonment, filth, illnesses, etc. The book was a shock to the public and prompted a parliamentary evaluation of the situation.