Francisco Javier de Balmis (2 December 1753 – 1819) was a Spanish physician who headed an 1804 expedition to Spanish America to vaccinate the populations against smallpox.

Born in Alicante, Balmis moved to Havana, and later to Mexico City. In Mexico City he was principal surgeon at the Hospital of San Juan de Dios. There he studied plant remedies for venereal disease, publishing Tratado de las virtudes del agave y la begonia (Treatise on the benefits of agave and begonia) in Madrid in 1794.

Back in Spain, he became the physician of King Charles IV. He persuaded the king to send an expedition to America to propagate the recently discovered vaccine against smallpox. Balmis was named head of the expedition, which sailed from Spain in 1804. He traveled to Puerto Rico, Puerto Cabello, Caracas, Havana, Mérida, Veracruz and Mexico City. The vaccine was carried as far as Texas in the north and New Granada in the south.

In Mexico City, he had to convince the viceroy, José de Iturrigaray, but he did so, and the viceroy had his son vaccinated.

In 1806 Balmis sailed from Acapulco for Manila, and in 1806 he arrived back in Spain. He returned to Mexico again in 1810.

He wrote Instrucción sobre la introducción y conservación de la vacuna (Instructions for the introduction and conservation of vaccine), and translated Moreau's work on the same subject, Tratado histórico - práctico, from the French. He died at Madrid in 1819.

Miguel Muñoz conserved and spread the vaccine in Mexico until 1844, when the project was taken over by his son Luis. After Luis Muñoz, Luis Malanco was in charge of the project.

Charles was the second son of Charles III and his wife Maria Amalia of Saxony. He was born at Naples (11 of November, 1748), while his father was King of the Two Sicilies. His elder brother Don Felipe was passed over for the two thrones as mentally retarded and epileptic. In Naples and Sicily he was styled as the Prince of Taranto.

Charles had inherited a great frame and immense physical strength from the Saxon line of his mother, granddaughter of August the Strong. When young he was fond of wrestling with the strongest countrymen he could find. While he was considered by many to be intellectually sluggish and quite credulous he was also known for his acts of kindness.

In 1788, Charles III died and Charles IV succeeded to the throne. Even though he had a profound belief in the sanctity of his office and kept up the appearance of an absolute, powerful monarch, he never took more than a passive part in the direction of his own government, occupying himself with hunting. The affairs of government he left to his wife and his prime minister. In 1792, Maria Luisa finally succeeded in ousting the Count of Floridablanca from office and had him replaced with Pedro Pablo Abarca de Bolea, Count of Aranda, the chief of the Aragonese party. However, in the wake of the war against Republican France, the liberal leaning Count of Aranda was replaced by Manuel de Godoy, a favorite of the Queen and allegedly her lover, who thenceforth enjoyed the lasting favor of the King.

Godoy continued Aranda's policy of neutrality towards France but after Spain protested against the execution of the deposed king in 1793, France declared war on Spain. After the declaration of war against Spain, Portugal and Spain signed a treaty of mutual protection against France. In 1795 France forced Godoy to conclude an alliance and declare war on the Kingdom of Great Britain.

In 1803, after smallpox had affected his daughter María Luísa, the king commissioned his doctor Francisco Javier de Balmis to bring the vaccine to the Spanish colonies on state expenses.

Spain remained an ally of France and supported the Continental Blockade until the British naval victory at Trafalgar. However, After Napoleon's victory over Prussia in 1807, Godoy again steered Spain back onto the French side. This switching back and forth devalued Charles' position as a trustworthy ally while the return to the French alliance increased Godoy's unpopularity and strengthened partido fernandista, the supporters of Crown Prince Ferdinand, who favored a close relationship with the United Kingdom.

When King Charles was told that his son Ferdinand was appealing to Napoleon against Godoy, he took the side of the minister. When the populace rose at Aranjuez in 1808 he abdicated on 19 March, in favor of his son, to save the minister who had been taken prisoner. Ferdinand took the throne as Ferdinand VII, but was mistrusted by Napoleon who had 100,000 soldiers in Spain by that time.

Charles IV found refuge in France, and became a prisoner of Napoleon: the latter, posing as arbiter, summoned both Charles IV and his son to Bayonne in April and coaxed Charles (who had a difficult time restraining himself from assaulting his son) to retract his earlier abdication and abdicate, on 5 May 1808, in favor of Napoleon. Napoleon then made his brother Joseph Bonaparte king in Spain.

Charles was then interned in Talleyrand's castle in Valençay. He accepted a pension from the French Emperor and spent the rest of his life between his wife and Godoy, staying briefly in Compiègne and longer in Marseille.

In 1812, he finally settled in Rome in the Palazzo Barberini. His wife, the former Queen, died on 2 January 1819. He died, reportedly of overwhelming despair and heartbreak because of the death of his wife, on 20 January 1819.

Charles IV married his first cousin Maria Louisa, the daughter of Philip, Duke of Parma, in 1765. The couple had fourteen children, six of whom survived into adulthood. Maria Luisa was widely considered a vicious and coarse woman who thoroughly dominated the king. During the lifetime of Charles IV, she led her husband into court intrigues against the prime minister, the Count of Floridablanca.