Born into a rich family, he was orphaned at a very young age. He studied in the Universidad Complutense, the Cisneros Institute and the Agustinos of El Escorial. He was awarded a Lawyer's license by the University of Zaragoza in 1897, and a doctorate by the Universidad Complutense in 1900.

In 1909 he achieved a position at the Main Directorate of the Registries and practiced the profession of civil law notary, and traveled to Paris in 1911. He became involved in politics and in 1914 joined the Reformist Republican Party led by Melquíades Álvarez. He collaborated in the production of various newspapers, such as El Imparcial and El Sol. During World War I he covered operations on the Western Front for various newspapers. His treatment was very sympathetic to the French, and he may have been subsidized by French military intelligence. Afterwards he directed the magazines Pluma and España between 1920 and 1924, founding the former with his brother - in - law Cipriano Rivas Cherif. He was secretary of the Ateneo de Madrid (1913 – 1920), becoming its president in 1930. He was a candidate for the province of Toledo in 1918 and 1923, but lost on both occasions. In 1926 he founded the Acción Republicana ("Republican Action") party with José Giral.

A strong critic of the dictatorship of Primo de Rivera, Azaña published an energetic manifesto against the dictator and King Alfonso XIII in 1924. In 1930, he was a signatory of the "Pact of San Sebastián", which united all the republican and regionalist parties in Spain against Primo de Rivera and the King.

On 12 April 1931, republican candidates swept the municipal elections. This was seen as repudiation of Primo de Rivera and the monarchy. Two days later, the Second Spanish Republic was proclaimed.

Niceto Alcalá - Zamora, prime minister of the provisional government of the Republic, named Azaña Minister of War on April 14. Alcalá - Zamora resigned in October, and Azaña replaced him as prime minister. When the new constitution was adopted on December 9, Azaña continued as prime minister, leading a coalition of left wing parties, including his own Acción Republicana and the Socialists (PSOE). (Alcalá - Zamora became President of the Republic.)

Azaña pursued some of the major reforms anticipated by the republican program. He reduced the size of the Army and removed some monarchist officers. He also moved to reduce the power and influence of the Roman Catholic Church, abolishing Church operated schools and charities, and greatly expanding state operated secular schools. The Cortes also enacted an agrarian reform program, under which large private landholdings (latifundia) were to be confiscated and distributed among the rural poor.

However, Azaña was a "middle - class republican", not a socialist. He and his followers were not enthusiastic for this program. The agrarian law did not include state funded collective farms, as the Socialists wanted, and was not enacted until late 1932. It was also clumsily written, and threatened many relatively small landholders more than the latifundists. And the Azaña government did very little to carry it out: only 12,000 families received land in the first two years.

In addition, Azaña did little to reform the taxation system to shift the burden of government onto the wealthy. Also, the government continued to support the owners of industry against wildcat strikes or attempted takeovers by militant workers, especially the anarcho - syndicalists of the Confederación Nacional del Trabajo (National Confederation of Labor or CNT). Confrontation with the CNT erupted in bloody violence at Casas Viejas (now Benalup), Castilblanco, and Arnedo.

Meanwhile, Azaña's extreme anti - clerical program alienated many moderates. In local elections held in early 1933, most of the seats went to conservative and centrist parties. Elections to the "Tribunal of Constitutional Guarantees" (the Republic's "Supreme Court") followed this pattern.

Thus Azaña came into conflict with both the right and far left. He called a vote of confidence, but two - thirds of the Cortes abstained, and Alcalá - Zamora ordered Azaña's resignation on 8 September 1933. New elections were held on 19 November 1933.

These elections were won by the right wing Confederación Española de Derechas Autónomas (CEDA) and the centrist Radical Republican Party. Radical leader Alejandro Lerroux became prime minister. Azaña temporarily withdrew from politics and returned to literary activity.

Azaña's self - imposed political retreat lasted only a short while; in 1934 he founded the Republican Left party, the fusion of Acción Republicana with the Radical Socialist Republican Party, led by Marcelino Domingo, and the Organización Republicana Gallega Autónoma (ORGA) of Santiago Casares Quiroga.

On 5 October 1934, the PSOE and Communists attempted a general left wing rebellion. The rebellion had a temporary success in Asturias and Barcelona, but was over in two weeks. Azaña was in Barcelona that day, and the Lerroux - CEDA government tried to implicate him. He was arrested and charged with complicity in the rebellion.

In fact Azaña had no connection with the rebellion, and the attempt to convict him on spurious charges soon collapsed, giving him the prestige of a martyr. He was released from prison in January 1935. Azaña then helped organize the Frente Popular ("Popular Front"), a coalition of all the major left wing parties for the elections of 16 February 1936.

The Front won the election, and Azaña became prime minister again on 19 February. His government included the PSOE and Communists. This alarmed conservatives, who remembered their attempt to seize power only 17 months earlier. The Azaña government proclaimed an immediate amnesty for all prisoners from the rebellion, which increased conservative concerns. Socialists and Communists were appointed to important positions in the Assault Guard and Civil Guard.

Also, with the Popular Front victory, radicalized peasants led by the Socialists began seizing land on 25 March. Azaña chose to legitimize these actions rather than challenge them. Radical Socialists vied with Communists in calling for violent revolution and forcible suppression of the Right. Political assassinations by Communists, Socialists, and anarcho - syndicalists were frequent, as were retaliations by increasingly radicalized conservatives.

However, Azaña insisted that the only danger to the Republic was from the Right. On 11 March, the government suppressed the Falange. He appeared unwilling to suppress or even to acknowledge the violence of the Left.

Azaña was a man of very strong convictions and has been called "the last great figure of traditional Castilian arrogance in the history of Spain." As a "middle class republican", he was implacably hostile to the monarchy and the Church. The CEDA, which was pro - Catholic, he therefore regarded as illegitimate, and also any and all monarchists, even those who supported parliamentary democracy. But Socialists and Communists, who were sound on these two issues, were acceptable, even as they called for "bolshevization" and the suppression of all "fascist" parties and newspapers, or spoke openly of armed insurrection.

Many historians consider the Popular Front's electoral victory as the first event in the immediate chain of events that led to the military rebellion against the Republic on 17 – 18 July 1936.

When the Cortes met in April, it removed President Alcalá - Zamora from office. On 10 May 1936, Azaña was elected President of the Republic; Quiroga succeeded him as prime minister. The Socialists and Communists extended their positions in the government. Azaña by this time was profoundly depressed by the increasing disorder, but could see no way to counter it.

Azaña repeatedly warned his fellow Republicans that the lack of unity within the government was a serious threat to the Republic's stability. But he did nothing to check the growing power of the radical Socialists. The political violence continued: there were over 200 assassinations in February through early July.

By July, the military conspiracy to overthrow the Republic was well underway, but nothing definite had been planned. Then on 13 July, José Calvo Sotelo, leader of the small monarchist group in the Cortes, was "arrested" and murdered by a mixed group of Socialist gunmen and Assault Guards. Azaña and Quiroga conspicuously failed to act effectively against the killers.

This was the last straw. On 17 July, right wing elements in the Spanish army proclaimed the overthrow of the Republic. The rebellion failed in Madrid, however. Azaña replaced Quiroga as Prime Minister with his ally Diego Martínez Barrio, and the government attempted a compromise with the rebels, which was rejected by General Mola.

At this time, most of the Spanish army had not joined the rebellion. A strong stand by Azaña in favor of maintaining the constitution against threats from any sector might have restored order. But Azaña did no such thing. Instead he brought in yet another prime minister, Giral, and the government began to "arm the people"; that is, distribute arms to Socialist and Communist party militias. In the next few days, the Republican state began to unravel. Socialist and anarcho - syndicalist radicals ran wild, taking up arms, forming unofficial militias, and attacking anyone considered a "fascist", including businessmen and priests. In many areas the "Reds" or anarchists became the effective rulers, while Azaña was paralyzed.

Most of the remainder of the army went over to the rebels. By 4 September, the rebel forces were approaching Madrid. Giral was replaced by the Socialist leader Francisco Largo Caballero. From then on Azaña was an impotent figurehead, passively approving the actions of the Socialists and Communists who now made up the government. On 13 September, he authorized Minister of Finance Juan Negrín to move the nation's gold reserve to wherever Negrin thought it would be secure. Negrin shipped it to the Soviet Union, which claimed it in payment for arms supplied to the Republic; Azaña said nothing.

In 1938, Azaña moved to Barcelona with the rest of the Republican government, and was cut off there when the rebel forces drove to the sea between Barcelona and Valencia. When Barcelona fell to the rebels on 26 January 1939, Azaña fled to France. He passed through the  Pyrenees on foot on 5 February 1939. On 3 March, he resigned as President of the Republic, rather than return to Madrid with the rest of the government. Both Nationalist and Republican commentators have condemned this decision as "desertion".

Azaña lived in exile in France after the war, being trapped there by the Nazi German occupation regime. He died on 4 November 1940, in Montauban. According to testimonies, he received the last sacraments before his death. The Vichy French authorities refused to allow his coffin to be covered with the Republican flag and he was covered instead with the flag of Mexico, whose then current government sympathized with the Spanish republican cause.

In his diaries and memoirs, on which he worked meticulously, Azaña vividly describes the various personality and ideological conflicts between himself and various Republican leaders, such as Largo Caballero and Negrín.

Azaña's writings during the Civil War contribute much to the study of the workings of the Republican government during the conflict. Along with his extensive memoirs and diaries, Azaña also produced a number of well known speeches. His speech on 18 July 1938 is one of the best known of these, in which he implores his fellow Spaniards to seek reconciliation after the fighting ends, emphasizing the need for "Peace, Pity, and Pardon."

Curiously, Azaña also wrote a play during the Civil War, La velada en Benicarló ("Vigil in Benicarló"). Having worked on the play during the previous weeks, Azaña dictated the final version while trapped in Barcelona during the May Days violence. In the play, Azaña uses various characters to espouse the various ideological, political, and social perspectives present within the Republic during the war, hence portraying and attempting to explain the rivalries and conflicts that were damaging the political cohesion of the Republic.

During the many years of his political activity Azaña kept a diary. Diarios completos: monarquía, república, Guerra Civil was published in 2003.

Born in Madrid, he was educated in the Institución Libre de Enseñanza, and studied in the Faculty of Philosophy and Letters at the University of Madrid, as well as at the Sorbonne in 1896, the Universities of Munich, Berlin and Leipzig in 1909 - 1910. In 1908, he joined the Partido Radical (Radical Party) established by Alejandro Lerroux.

He became a member of the Agrupación Socialista Madrileña (the socialist circle in Madrid) in 1912 and in that same year he was offered the Chair of Fundamental Logic in the Faculty of Philosophy and Letters. Soon after, Besteiro became a member of Unión General de Trabajadores (UGT) trade union, and of the Spanish Socialist Workers' Party (PSOE). In 1913 he married Dolores Cebrián, a professor of physics and natural science at the teachers' training college in Toledo.

In 1917, after the general strike of that year he was tried as a member of the strike committee and sentenced to life imprisonment. He was elected as a member of the town council of Madrid in the amnesty campaign. In the following year, he was elected to the Cortes Generales (Spanish Parliament) as deputy for Madrid.

During the dictatorship of Miguel Primo de Rivera he was in favor of collaboration with the Dictator - who had offered the participation of UGT in governing the country. To a certain extent, it appeared to be a success in the mid 1920s. However, opinion within the PSOE turned against him as the Primo de Rivera regime became even more unpopular in the economic downturn. In mid 1930s Besteiro became isolated in his opinions on collaboration in opposition to the front established by the Pact of San Sebastián. Bestiero also opposed the participation of UGT in the December 15, 1930 general strike. At a joint meeting of the PSOE and UGT he resigned as President of both the party and the union in February 1931. In the same year he was elected a councilor of the Madrid town council.

After the establishment of the Second Spanish Republic, Besteiro was elected Speaker of the Constituent Cortes. During his period as President of the Cortes, he seemed to become more conservative in his political views. He resigned as President of the UGT in January 1934. Opposing the growing radicalization of the Socialist movement, he disapproved the participation of various socialists in the armed uprising of October 1934. In February 1936, he won the highest number of votes of any candidate in Madrid in the Popular Front elections.

When the Spanish Civil War broke out Besteiro continued to work in the university as a Dean of the Faculty of Philosophy and Letters and carry out his duties as a parliamentary deputy and councilor of the town council in Madrid. Against the persuasions of his friends he refused to leave Madrid and seek exile. Manuel Azaña, the Spanish Republican President, chose Besteiro as the representative to the coronation of the new British King George VI in London on May 12, 1937. Besteiro believed it was to be a peace mission. There he met with Sir Anthony Eden but no significant results followed. After the failure of his mission in London he returned to work in the town council of Madrid and withdraw from official public life. He stopped attending the Agrupación Socialista Madrileña and the parliamentary group meetings.

With the news of the fall of Barcelona on January 26, 1939, and Azaña's resignation as President of the Republic, Besteiro decided to find ways to achieve peace and stop the resistance. He contacted Colonel Segismundo Casado and, on March 5, announced the creation of a Consejo Nacional de Defensa. As a result, about 2,000 people were killed in the uprising against the government of Juan Negrín and its Communist Party of Spain allies.

After the fall of Madrid to the Nationalists on March 28, 1939, Bestiero was arrested by Francoist forces. On July 8, he faced a court martial and was sentenced to thirty years. He was sent first to the Monasterio de Dueñas until the end of August 1939 and then to the prison of Carmona, where he died the following year.