In August 1968, the Soviet Union invaded Czechoslovakia to crush the liberalizing reforms of Alexander Dubček's government during what was known as the Prague Spring. A group of Czech students including Palach made a suicide pact intending to sacrifice themselves in protest of the invasion. Prague - born Palach was the first to set himself on fire, in Wenceslas Square, on 16 January 1969.

According to Jaroslava Moserová, a burns specialist who was the first to provide care to Palach at the Charles University Faculty Hospital, Palach did not set himself on fire to protest against the Soviet occupation, but did so to protest against the "demoralization" of Czechoslovakian citizens caused by the occupation.

Most of the other students did not go through with their part, after the well - publicized pleas Palach made on his deathbed about the degree of pain they faced.

The funeral of Palach turned into a major protest against the occupation, and a month later (on 25 February 1969) another student, Jan Zajíc, burned himself to death in the same place, followed in April of the same year by Evžen Plocek in Jihlava.

Palach was initially interred in Olšany Cemetery. As his gravesite was growing into a national shrine, the Czechoslovak secret police (StB) set out to destroy any memory of Palach's deed and exhumed his remains on the night of 25 October 1973. His body was then cremated and sent to his mother in Palach's native town of Všetaty while an anonymous old woman from a rest home was laid in the grave. Palach's mother was not allowed to deposit the urn in the local cemetery until 1974. On 25 October 1990 the urn was officially returned to its initial site in Prague.

On the 20th anniversary of Palach's death, protests ostensibly in memory of Palach (but intended as criticism of the regime) escalated into what would be called "Palach Week". The series of anticommunist demonstrations in Prague between 15 and 21 January 1989 were suppressed by the police, who beat demonstrators and used water cannons, often catching passers by in the fray. Palach Week is considered one of the catalyst demonstrations which preceded the fall of communism in Czechoslovakia 11 months later.

After the Velvet Revolution, Palach (along with Zajíc) was commemorated in Prague by a bronze cross embedded at the spot where he fell outside the National Museum, as well as a square named in his honor. The Czech astronomer Luboš Kohoutek, who left Czechoslovakia the following year, named an asteroid which had been discovered on 22 August 1969, after Jan Palach (1834 Palach). There are several other memorials to Palach in cities throughout Europe, including a small memorial inside the glacier tunnels beneath the Jungfraujoch in Switzerland.

Several later incidents of self - immolation may have been influenced by the example of Palach and his media popularity. In the spring of 2003, a total of six young Czechs burned themselves to death, notably Zdeněk Adamec, a 19 year old student from Humpolec who burned himself on 6 March 2003 on almost the same spot in front of the National Museum where Palach burnt himself, leaving a suicide note explicitly referring to Palach and the others who had committed suicide in the 1969 Prague Spring.)

Just walking distance from the site of Palach's self - immolation, a statuary in Prague's Old Town Square honors iconic Bohemian religious thinker Jan Hus, who was burned at the stake for his beliefs in 1415. Himself celebrated as a national hero for many centuries, some commentary has linked Palach's self - immolation to the execution of Hus.

The music video for the song "Club Foot" by the band Kasabian is dedicated to Palach. The composition "The Funeral of Jan Palach" performed by The Zippo Band and composed by Phil Kline is a tribute. Palach is mentioned in The Stranglers' bassist, Jean - Jacques Burnel's solo album of 1979, Euroman Cometh.

After seeking political asylum in the United States, Polish artist Wiktor Szostalo commemorated Jan Palach in his "Performance for Freedom" proclaiming "I am Jan Palach. I'm a Czech, I'm a Pole, a Lithuanian, a Vietnamese, an Afghani, a betrayed You. After I've burnt myself a thousand times, perhaps we'll win".

On the occasion of the 40th anniversary of the death of Jan Palach, a statue sculpted by András Beck as a tribute to the student was transported from France to the Czech Republic. The statue was installed in Mělník, the city where Jan Palach did his studies.

Italian songwriter Francesco Guccini wrote a song "La Primavera di Praga"" in dedication to Jan Palach, compared to religious scholar Jan Hus: "Once again Jan Hus is burning alive". Polish singer Jacek Kaczmarski wrote a song about Palach's suicide, called "Pochodnie" ("Torches").

The Luxembourg based Welsh composer Dafydd Bullock was commissioned to write "Requiem for Jan Palach" (op 182) to commemorate the fortieth anniversary of Palach's suicide. It includes a setting of words which appeared briefly on a statue in Wenceslas Square after the event, before being erased by the authorities: "Do not be indifferent to the day when the light of the future was carried forward by a burning body".

Palach featured in a monologue radio play entitled "Torch No 1" on BBC Radio 4, directed by Martin Jenkins, and written by David Pownall. Palach was played by Karl Davies.

French documentary filmmaker Raymond Depardon directed a 1969 film about Jan Palach.

Norwegian songwriter Hans Rotmo mentioned Palach's name among other notable political activists such as Victor Jara and Steve Biko in his 1989 song "Lennon Street".

A sequence of poems exploring the implications of Palach's death called One Match by the poet Sheila Hamilton were published in issue 51 of the Dorset based poetry serial, Tears in the Fence (ed. David Caddy) in 2010.

The Jan Palach Square in central Prague was named after Palach, there are Palachovo náměstí (Palach Square) in Brno. He also had streets named after him in Luxembourg city (Luxembourg), Angers and Parthenay (France), Kraków (Poland), Assen (Netherlands), Varna (Bulgaria) and Nantwich (United Kingdom). In Rome (Italy) (as well as in many other Italian towns), there is a central square named after Palach with a commemorative statue.

The oldest rock club in Croatia is named Palach. It is situated in Rijeka since 1969 to this day. There is a bus station in the town of Curepipe, Mauritius named after Jan Palach. A student hall in Venice, Italy, on the Giudecca island has also been given the name of Jan Palach.