• Manga Artist, Film Director and Screenwriter Satoshi Kon, 1963

 

In 1993, Kon scripted and co-produced the fifth episode of the original video animation JoJo's Bizarre Adventure. In 1997, Kon began work on his directorial debut Perfect Blue (based on Yoshikazu Takeuchi's novel of the same name). A suspense story centered around a pop idol, it was the first film by Kon to be produced by Madhouse. Kon was initially unsatisfied with the original screenplay written by the author and requested to make changes to it. Aside from maintaining three elements of the novel ("idol", "horror" and "stalker"), Kon was allowed to make any changes he desired. The screenplay was written by Sadayuki Murai, who worked in the idea of a blurred border between the real world and imagination.

Following Perfect Blue, Kon considered adapting the Yasutaka Tsutsui novel Paprika (1993) into his next film. However, these plans were stalled when the distribution company for Perfect Blue, Rex Entertainment, went bankrupt. Coincidentally, Kon's next work would also feature the theme of the blending of imagination and reality. In 2002, Kon's second film, Millennium Actress, was released to the public. The film centers around a retired actress who mysteriously withdraws from the public eye at the peak of her career. Having the same estimated budget as Perfect Blue (approximately 120,000,000 yen), Millennium Actress garnered higher critical and financial success than its predecessor and earned numerous awards. The screenplay was written by Sadayuki Murai, who utilized a seamless connection between illusion and reality to create a "Trompe - l'œil kind of film". Millennium Actress was the first Satoshi Kon film to feature Susumu Hirasawa, whom Kon was a long time fan of, as composer.

In 2003, Kon's third work, Tokyo Godfathers, was announced. The film centers on a trio of homeless persons in Tokyo who discover a baby on Christmas Eve and set out to search for her parents. Tokyo Godfathers cost more to make than Kon's previous two films (with a budget of approximately 300,000,000 yen), and centered on the themes of homelessness and abandonment, with a comedic touch worked in. The screenplay was written by Keiko Nobumoto.

In 2004, Kon released the 13 episode television series Paranoia Agent, in which Kon revisits the theme of the blending of imagination and reality, as well as working in additional social themes. The series was created from an abundance of unused ideas for stories and arrangements that Kon felt were good but did not fit into any of his projects.

In 2006, Paprika was announced, after having been planned out and materializing for several years. The story centers on a new form of psychotherapy that utilizes dream analysis to treat mental patients. The film was highly successful and earned a number of film awards. Kon summed up the film with "Kihonteki na story igai wa subete kaeta" (基本的なス トーリー以外は全て変えた) — roughly, "Everything but the fundamental story was changed." Much like Kon's previous works, the film focuses on the synergy of dreams and reality.

After Paprika, Kon teamed up with Mamoru Oshii and Makoto Shinkai to create the 2007 NHK television production Ani*Kuri15, for which Kon created the short Ohayō. That same year, Kon helped establish and served as a member of the Japan Animation Creators Association (JAniCA).

Following Ohayō, Kon began work on his next film The Dream Machine. In May 2010, Kon was diagnosed with terminal pancreatic cancer. Given half a year to live, Kon chose to spend the remainder of his life in his home. Shortly before his death Kon composed a final message, which was uploaded to his blog by his family upon his death. As Kon explained in the message, he chose not to make news of his rapidly advancing illness public, in part out of embarrassment at how drastically emaciated and ravaged his body had become. The result was that the announcement of his death was met with widespread shock and surprise, particularly given that Kon had shown no signs of illness at relatively recent public events, as the cancer progressed to a terminal state a matter of months after being diagnosed. Kon died on August 24, 2010 at the age of 46.

As of 2013, the completion of Dreaming Machine remains uncertain due to funding difficulties, with only 600 of the 1500 shots being animated. At Otakon 2012, Madhouse founder Masao Maruyama stated: "Unfortunately, we still don't have enough money. My personal goal is to get it within five years after his passing. I'm still working hard towards that goal."

Satoshi Kon's most prominent influences were the works of Philip K. Dick and Yasutaka Tsutsui. Kon viewed various manga and anime up until high school. He was particularly fond of Space Battleship Yamato, Future Boy Conan, Galaxy Express 999 (1978), Mobile Suit Gundam and Domu. Western films also served as an influence, most notably George Roy Hill's Slaughterhouse-Five (1972), The City of Lost Children (1995) and the works of Terry Gilliam (particularly Time Bandits (1981), Brazil (1985) and The Adventures of Baron Munchausen (1989)). In addition to Gilliam, he also blogged about watching Monty Python. He was fond of the works of Akira Kurosawa, and worked in a reference to him in Paprika. However he claimed not to be familiar with much of Japanese film in general.